An unspeakable ancient evil pervades the water around Dante's Island once every 30 years. Six friends, home from college, learn of the phenomena's imminent return and decide to investigate. They ignore the dire warnings of the only known survivor of the black and set out to the island. Once there they find themselves trapped with two mysterious strangers who claim to be scientists doing their own research. As the body count rises, the only thing they can count on is death.

Two couples drive to a secluded house in the desert for a weekend getaway, each with their own baggage, expectations, and secrets. Upon their arrival, they’re met by two strangers, claiming to have rented the house as well.

What starts as just another delivery becomes the catalyst for life-shattering trouble. With Brian injured and evidence mounting against them, three friends find themselves on the run from the law. In a panic, Brian turns to his mentor and ringleader, Bear, and together they come up with a perfect scheme of betrayal and murder.

A man on a mountain vacation with two friends goes home with a woman he's never met. He wakes up to find that one of his kidneys has been surgically removed. He spends the rest of the film trying to find out who did it.