As an outbreak of leprosy engulfs 19th-century colonial Hawai'i, a small group of infected Native Hawaiians resist government-mandated exile, taking a courageous stand against the provisional government. Inspired by real-life events.

In a pandemic-stricken world, Stan and Cindy lead a group of strangers thrown together as they attempt to escape northward away from the inflicted known as the Crossed, those affected by a mysterious disease appear to have a cross on their foreheads, and follow their worst impulses.