After surviving a sneak attack on himself and fellow agents Jimmy and Gene as they were transporting drug kingpin Raymond Manta out of a Mexican jail, FBI agent Jeff Douglas becomes an uwitting pawn of the White Hand drug cartel. Mistakenly told that his already murdered family is being held hostage, Jeff is forced to turn one-time courier for the White Hand, whose leaders are Manta and four others named Helmut Vitch, Milt Kowalski, Russ LaFleur, and Hansel Lee. After surviving a car-bombing in Las Vegas, Jeff learns the truth about his family being murdered, and he sets out to exterminate the White Hand cartel. Unofficially aided by an agent named Megan, whose mother was raped and murdered years ago, Jeff steals FBI files and begins his campaign of revenge on the White Hand cartel.

A ring of call girls leaves the "business" when one of them is murdered. The survivors change their names and leave town. However, they are reunited 15 years later when another one of them is murdered and the rest realize that they are all being tracked by the same serial killer.