Fai (Intira Charoenpura) is a girl who's mysteriously connected to the number "6", which is related to her bad luck. On the night before her 24th birthday (2+4 = 6) , her friends come to celebrate. Ong (Watcharachai Sataphitak), one of her friend who has the knowledge of horoscope finds the snake star in the sky, which rarely appears in rainy season. It's the sign of bad luck that could claim their life, but Khan (Ray Macdonald) insists to everyone that's absolutely nonsense and wants to prove the truth. Following Khan's belief, all 6 friends head to a desolate mansion that has been told about 6 coffins lying somewhere in the mansion. They come face to face with supernatural events that come along with their ultimate fear.

A witch is burned on the stake, but her spirit has possessed a giant spider and is on the rampage. Enraged and thirsty for vengeance, a mob of torch bearing villagers march through an eerie wood in search of an evil child-eating woman. But dealing their own brand of justice, this might just be the worst mistake of their lives, as the one they seek possesses a darker power then they would have ever imagined. Spider woman spins the nightmarish tale of an unsuspecting group of people encountering a mystical world of buried secrets, human possession and gigantic spiders. Evil never takes kindly to those who oppose it...and in this case, its counterattack pounces with eight-legged agility.