Under My Skin is inspired by real people and events, and it accurately depicts the realities, triumphs, and struggles of people living with HIV, while navigating an important conversation about acceptance and tolerance. The show introduces us to a number of characters – Jonathan, Greg, Syd, and Mario whose relationships are tested when Jonathan gets infected; Dino, an HIV-positive teen whose status is discovered through a contraction of tuberculosis; Mary Rose, a mother who unknowingly passed down the virus to her son after getting it from her husband; a gay beauty parlor employee experiencing work-related discrimination, and more. Their stories of love, pain, and acceptance are revealed through Dr. Gemma Almonte, who is studying the spread of the devastating virus.

Jhonabelle's dream of attending a prestigious university is shattered when her aunt abandons her and her brother, Jhanjhan leaving them with nothing but a small sum of money. Struggling to make ends meet, Jhonabelle sets aside her aspirations and looks for a job to sustain their daily needs. But her brother's health takes a turn for the worse when he is diagnosed with Leukemia, leaving Jhonabelle on the verge of giving up. Desperate to earn money, she turns to vlogging and creates prank videos that goes viral, allowing her to raise funds for her brother's treatment. However, her world comes crashing down when someone steals all the money she saved. Despite seeking help from the authorities and her fans, she is left helpless and alone while some mocks her thinking that the incident is just another desperate move to get views.

Just days before her team's tryouts for the Olympics, dedicated young gymnast Sunshine discovers she is pregnant. Now she must embark on a desperate and risky journey to fight for her dream.

Cynical filmmakers plan on producing a bleak, independent film dealing with poverty and prostitution in the hopes of scoring free travel to international film festivals.