In 1977, a disco star takes a mysterious kind of acid at a party that causes everyone to suddenly vanish. In the present day, a one eyed drug dealer and the man that punched his eye out return to the scene to take the acid with a strange young woman.

Roger is a mortician who, when examining the body of a beautiful young woman named Eve, finds himself faced with an internal crisis that sends him on a dreamlike journey.

A family struggles to survive when they are trapped in a country house with The Chupacabra lurking outside. However, chaos spirals when La Llorona is summoned to kill.