Raul Portugis (Redford White) is a physics professor from Antique province who had relocated to Manila and became a witness to a crime. This, plus the experience of handling a difficult class and being a newcomer in the city, results in one of the most humiliating chapters in his life. The soul of the slain teacher Jeffrey (Richard Reynoso) will inhibit his body to use him to solve the crime of his murder and bring the murderer to justice while he teaches the class he left.

Basketball star Benjie Paras and funny man Herbert Bautista play cousins Donato and Buknoy, star player and coach of the Brgy. Maligaya basketball team. The team needs to win the league championship to help their barangay.

Teresa (Rustica Carpio) has worked for the Bautista family since she was seventeen. She was the nanny of siblings Stella, Vince and Andre (Jackie Lou Blanco, Bobby Andrews and Ryan Agoncillo), and their mother. The three have all moved abroad in their adulthood, but all reunite back at home with the passing of their mother. With no one left to stay in the country, it is decided that all of their properties will be sold, including the house they grew up in. But they are faced with the problem of what to do with the elderly Teresa, who has no money saved, and little contact with her relatives.

Nothing prepared ROD (Ryan Agoncillo ) and MIA ALVAREZ (Judy Ann Santos) for the major changes that took place in their lives. ROD worked as a manager of a bank while MIA opted to remain a housewife taking care of their two children — MIGO and KAYE — with an occasional sideline of selling insurance. MIA gave up her promising career in sales because ROD wanted to be the padre de familia. For ROD, it was the role of the man to provide for his wife and children … in the same manner that there was a clear cut delineation as to what are the duties of a husband from that of the wife.

A handsome bachelor rumored to be gay and a free-spirited woman are forced to work together to help their company.

A funny story about three female friends. Karen is the smart and fashionable one among the three. Love is the cousin of Karen. She works in the cosmetics section of a department store, and dreams of becoming a beauty queen someday. Yolly is the businesswoman of the group. She is into the buy and sell business. The story runs when Love joins a beauty contest, where they find out that her roommate, Greta, is the new girlfriend of Karen's philandering boyfriend, Artie, and is also the god brother of Yolly's policeman boyfriend, SPO Pablito, who dumped her. Karen, Love and Yolly tire out all their efforts for Love to win the contest and teach their ex-boyfriends a valuable lesson.

Continuing the tradition of national artist Ishmael Bernal's benchmark film Working Girls after 25 years, Working Girls of 2010 depicts the role of women in the new millennium. Seven women of different backgrounds, stories and personalities entwined in a colorful story of family, love and life.

The Battle of Tirad Pass was fought between Filipino revolutionary forces and Americans of the 33rd Infantry Regiment in Ilocos Sur. Brigadier General Gregorio del Pilar led the Filipinos, while Major Peyton March led the Americans. The battle resulted in the death of Del Pilar, along with 51 Filipino soldiers.