While investigating a terroristic threat that goes viral online, Korean authorities discover that a suspect has recently boarded an international flight bound for the United States. When a healthy passenger on the same flight suddenly dies a gruesome death of unknown cause, panic erupts both in-flight and on the ground. With steadily decreasing fuel and international refusals to offer aid, the captain and crew will be forced to take unprecedented emergency measures in an attempt to save the lives of their passengers.

Su-mi is unable to keep her mother hospitalised because her hospital bills continue to be delayed, and the hospital's 'interim settlement' forces her to discharge her. Believing that if she prays just a little more, her mother will recover, she causes a scene at the hospital and forcibly takes her mother home. Despite everything not going as planned, she refuses to give up hope that she can still send her mother on the flower tour starting next week.

In the dead of night, a body donated for organ transplants mysteriously disintegrates into ashes. Soon after, five recipients, given a heart, corneas, lungs, liver, and kidneys, begin to develop supernatural powers. A teenage girl gains immense strength, a hipster manipulates electromagnetic waves, a novelist summons powerful gusts, a factory manager can heal others, and a woman discovers a strange, still-unidentified ability. Together, they form a reluctant but heroic team known as "HI-FIVE." But they aren't the only ones transformed. A cult leader who received the donor’s pancreas gains the terrifying power to drain life energy and sets his sights on stealing the abilities of HI-FIVE to achieve godlike domination.