After suffering a potentially career-ending brain trauma, Cameron Cade receives a lifeline when his hero, legendary eight-time Championship quarterback and cultural megastar Isaiah White, offers to train Cam at Isaiah's isolated compound that he shares with his celebrity influencer wife. But as Cam's training accelerates, Isaiah's charisma begins to curdle into something darker.

Jeff and his friends head down to Mexico, only to discover the hard way that Jeff is a dead ringer for the infamous cartel leader El Tigre who’s gone missing. After being captured by rivals and then rescued by El Tigre’s forces, Jeff has to pretend to be their ruthless leader until he can find his friends and a way home.

Andy Sachs returns to Runway as Miranda Priestly navigates a new media landscape and Runway's position within. The duo reconnect with former assistant Emily Charlton, now the head of a luxury brand that possesses funding which could ensure Runway's survival.