A miracle pill intended to save the world causes unforeseen side-effects forcing the surviving gays and bible thumpers in a small Texas town to join forces or fall prey to the flesh craving mutants.

A group of trannies are violently bashed and left for dead. The surviving ladies regain consciousness, confidence, and courage ready to seek out revenge on the ones who attacked them.

Four desperate bank robbers are forced to abandon their lucrative heist plans and become the reluctant heroes when two of their hostages turn out to be psychotic killers who won't stop until everyone in the bank has been ruthlessly slaughtered. As the police surround the building and the killers begin methodically executing the hostages.