A UFC Middleweight Championship rematch between current champion Alex Pereira (also former Glory Middleweight and Light Heavyweight Champion) and former champion Israel Adesanya is expected to headline the event. The pairing previously met at UFC 281 in which Pereira captured the title by fifth round knockout. The two also previously met twice in kickboxing matchups. The first in April 2016 which Pereira won by unanimous decision. Their second meeting took place at Glory of Heroes 7 in March 2017 which Pereira won by third round knockout.

UFC 200: Tate vs. Nunes was a mixed martial arts event produced by the Ultimate Fighting Championship held on July 9, 2016, at the T-Mobile Arena on the Las Vegas Strip in Paradise, Nevada. This event suffered a major hit only three days before it happened, as it was announced that Jones was pulled out by USADA due to a potential Anti-Doping Policy violation stemming from an out-of-competition sample collection on June 16. Cormier declared he would still fight if an opponent brought to him "made sense". It was announced that former UFC Middleweight Champion Anderson Silva would replace Jones on less than two days' notice and face Cormier in a three-round non-title light heavyweight bout. Due to those major changes, the already scheduled UFC Women's Bantamweight Championship bout between then champion Miesha Tate and top contender Amanda Nunes was revealed as the new main event.

UFC Fight Night 27: Condit vs. Kampmann 2 was a mixed martial arts event held on August 28, 2013, at the Bankers Life Fieldhouse in Indianapolis, Indiana. The main event was a rematch between Martin Kampmann and former UFC Interim Welterweight Champion and former WEC Welterweight Champion Carlos Condit. In their first encounter at UFC Fight Night 18 in 2009, Kampmann defeated Condit (who was making his promotional debut) via split decision.

UFC on ESPN 52: Dariush vs. Tsarukyan was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on December 2, 2023, at the Moody Center in Austin, Texas, United States. A lightweight bout between Beneil Dariush and Arman Tsarukyan headlined the event.

UFC 183: Silva vs. Diaz was a mixed martial arts event held on January 31, 2015, at MGM Grand Garden Arena in Las Vegas, Nevada. The event was headlined by a middleweight bout between former UFC Middleweight champion Anderson Silva and former WEC & Strikeforce Welterweight champion Nick Diaz.

UFC on ABC 6: Whittaker vs. Aliskerov was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on June 22, 2024, at the Kingdom Arena in Riyadh, Saudi Arabia. A middleweight bout between former UFC Middleweight Champion (also The Ultimate Fighter: The Smashes welterweight winner) Robert Whittaker and Ikram Aliskerov headlined the event.

UFC on Fox 25: Weidman vs Gastelum was a mixed martial arts event produced by the Ultimate Fighting Championship held on July 22, 2017 at the Nassau Veterans Memorial Coliseum in Uniondale, New York. The event was headlined by a middleweight bout between former UFC Middleweight Champion Chris Weidman and The Ultimate Fighter: Team Jones vs. Team Sonnen middleweight winner Kelvin Gastelum.[

UFC 206: Holloway vs. Pettis was a mixed martial arts event produced by the Ultimate Fighting Championship (UFC) held on December 10, 2016, at the Air Canada Centre in Toronto, Ontario, Canada. A featherweight bout between Max Holloway and former UFC Lightweight Champion Anthony Pettis was shifted to the headlining spot after numerous fights fell through.

UFC 180: Werdum vs. Hunt was a mixed martial arts event held on November 15, 2014 at Arena Ciudad de México in Mexico City, Mexico.

UFC Fight Night 122: Bisping vs. Gastelum was a mixed martial arts event produced by the Ultimate Fighting Championship and held on November 25, 2017, at Mercedes Benz Arena in Shanghai, China.