Sarah Silverman appears before an audience in Los Angeles with several sketches, taped outside the theater, intercut into the stand-up performance. Themes include race, sex, and religion. Her comic persona is a self-centered hipster, brash and clueless about her political incorrectness. A handful of musical numbers punctuate the performance.

Short film directed by Rupert Sanders based on the comic book by Charles Burns. The story deals with the aftermath of a sexually transmitted disease which causes grotesque mutations in teenagers.