A solar eclipse seems to be interfering with the menstrual cycle of women everywhere and wreaking havoc on their hormones. The result is a need to kill any and every man they see. Some women fight it, and some sink into it like a comfy couch. By the time the film is done, the body count is high, lots of blood has been spilled, and women everywhere become murder machines.

Two friends, both named Frank, accidentally obtain a suitcase at the airport. It contains incriminating evidence against a mafia boss, who sends his Terminator-like lackie to find them. The Franks hide by impersonating make-up women for a beauty pageant. While in drag, the mafioso falls in love with one of the Franks.