When a massive, unmanned locomotive roars out of control, the threat is more ominous than just a derailment. The train is laden with toxic chemicals, and an accident would decimate human life and cause an environmental disaster. The only hope of bringing the train to a safe stop is in the hands of veteran engineer Frank Barnes, and young conductor Will Colson, who must risk their lives to save those in the runaway's path. Inspired by true events.

Based on Michael Chabon's novel, the film chronicles the defining summer of a recent college graduate who crosses his gangster father and explores love, sexuality, and the enigmas surrounding his life and his city.