The PFL 10 mixed martial arts event for the 2021 season of the Professional Fighters League was held on October 27, 2021. This was the finale of the playoffs for all divisions, with the winners getting $1 million cash prize. Kayla Harrison, a two-time Olympic gold medalist in judo and is seeking her second PFL championship, headlined the PFL event opposite Taylor Guardado, who emerged as an unexpected finalist in 2021. The event also featured five other finals matchups, with the winner of each weight class taking home PFL's trademark $1 million prize.

The PFL 8 mixed martial arts event for the 2021 season of the Professional Fighters League was held on August 19, 2021. This was the second event for of the playoffs with the Heavyweight and Women's Lightweight divisions competing. This event aired on ESPN, with the prelims on ESPN+. Kayla Harrison, the only two-time Olympic gold medalist in judo in the history of the United States, entered her second PFL playoffs unbeaten in 10 pro bouts. She faced Genah Fabian who held a 4-1 record and had won both of her PFL regular season bouts against Julija Pajic and Laura Sanchez to advance to the playoffs.

The PFL 9 mixed martial arts event for the 2022 season of the Professional Fighters League was held on August 20, 2022, at the Copper Box Arena in London, England. This was the start of the playoffs for the Women's Lightweight and Featherweight divisions. The Women's Lightweight bracket sees UFC vet Larissa Pacheco take on Olena Kolesnyk while Kayla Harrison faces Martina Jindrová in the other lightweight semifinal.

The PFL 2 mixed martial arts event for the 2018 season of the Professional Fighters League was held on June 21, 2018, at the Chicago Theatre in Chicago, Illinois. It was the second regular season event of 2018 and included only fights in the lightweight and light heavyweight divisions.

The PFL 4 mixed martial arts event for the 2019 season of the Professional Fighters League was held on July 11, 2019, at the Ocean Resort Casino in Atlantic City, New Jersey. This was the fourth regular season event of 2019 and include fights in the welterweight and women's lightweight divisions.

The PFL 10 mixed martial arts event for the 2019 season of the Professional Fighters League, the 2019 PFL Championship, was held on December 31, 2019, at the Hulu Theater at Madison Square Garden in New York City, New York.

The PFL 7 mixed martial arts event for the 2019 season of the Professional Fighters League was held on October 11, 2019, at the Mandalay Bay Events Center in Las Vegas, Nevada. Kayla Harrison was initially scheduled to face Genah Fabian at this event. However, Fabian missed weight and was replaced by Bobbi-Jo Dalziel.

The PFL 6 mixed martial arts event for the 2021 season of the Professional Fighters League was held on June 25, 2021. This was the third regular season event of the tournament and included fights in the Heavyweight and women's Lightweight divisions. This event will aire on ESPN2, with the prelims on ESPN+. The event was headlined by Two-time Olympic gold medalist Kayla Harrison and Cindy Dandois.

The event was headlined by a heavyweight bout, contested by the former UFC Heavyweight champion Fabrício Werdum and Renan Ferreira. In the co-main event, the 2019 PFL Lightweight champion Kayla Harrison fought Mariana Morais.

The PFL 3 mixed martial arts event for the 2022 season of the Professional Fighters League will be held on May 6, 2022, at the Esports Stadium Arlington in Arlington, Texas. This will be the third regular season event of the tournament and included fights in the Women's Lightweight and Welterweight divisions.