A man wrongfully convicted of murder escapes custody and goes in search of the real killer. The problem is that he only has one clue to go on.

Ken Maynard's exceptionally intelligent horse, Tarzan the Wonder Horse, is the star of this western about evil cowboy Steve Frazer (Welch) who gathers horses for slaughter, whose meat is sold to pet food manufacturers. The wild horse Tarzan frees the doomed horses from their corrals, and Frazer convinces the Sheriff that Tarzan is a threat and can be shot on sight. Local cowboy Ken Benson (Maynard) and rancher Pat Riley (Kennedy) work together to clear Tarzan's good name and put Frazier behind bars for his evil deeds.

A cowboy and a beautiful girl inherit a supposedly haunted gold mine.

Newspaper editor Bill Temple arrives in Boom Town planning to expose Jim Blane as a crook. When Blane's henchman Buck fails to kill Temple, Blane prepares to flee with his money. But a sudden announcement of a gold strike empties the town. Blane heads after his henchmen who have taken his money and Temple heads after Blane.

A kindly, elderly couple who run a New York City boarding house form the steady center around which the lives and loves of their various residents unfold. Borrowed money, a lovelorn chorus girl, and a tragic misunderstanding set in motion the chain of events in East of Fifth Avenue’s tender pageant of life.