The young women who board a liner in the port of Genoa have no idea that they are being watched, nor what actually awaits them. Harald, who had recruited them for the trip with false promises, watches unnoticed, but cannot enjoy his success, because there are many people interested in the lucrative business with the girls, who are to be forced into prostitution. After two gangsters shoot the shady Lemaire, who had previously blackmailed Harald, he can return unmolested to Berlin to his compagnon Rolf, but the competition remains on his heels and threatens to disrupt the business.

After a historical excursus on the most common venereal diseases, doctors report on various cases of infection, each illustrated in the manner of amateurish reportage films.

Rosy, a 15 year old, escapes the protectory and finds shelter at Helens, a singer. But Helen's care is just temporary and soon new troubles find her.