A father in a Texas border town starts trafficking drugs to pay for his son's cancer treatment.

Negative is set in the American southwest and follows Natalie, a former British spy who flees Los Angeles for Phoenix after a deal with a cartel goes wrong. She's joined by Hollis, a street photographer who has put his life at risk by taking Natalie's photo at the wrong time and in the wrong place.

While rocking out at weddings and waiting for his band blow up, Tony strikes up an intense romance with Terri, a beautiful dancer. But when Terri’s gangster husband learns of their affair, the beleaguered lovers must run for their lives.