Tod Lubitch is born with a deficient immune system. As such, he must spend the rest of his life in a completely sterile environment. His room is completely hermetically sealed against bacteria and virus, his food is specially prepared, and his only human contact comes in the form of gloved hands. The movie follows his life into a teenager.

A high school girl who needs a ride accepts one from a boy she doesn't know. He then forces her to participate in a robbery, in which a clerk is killed. They are soon caught, and the girl, despite her protestations of innocence, is convicted of first-degree murder and sent to prison. Once she gets there, she finds out that her troubles are just beginning.

On a bet with one of his practical-joking partners, a Los Angeles lawyer responds to an ad from a pretty Chicago magazine writer offering herself as a bridal candidate as an investigative reporting assignment, and then makes another bet that he can keep the relationship platonic for two weeks.

Stine is eighteen and has finished school. Her parents have are divorced, and the father has a new wife. Stine is not so anxious finding a regular job, She would like to be an actor.