The Party Animal is a documentary-style comedy about a sex-starved man, Pondo Sinatra, a 26-year-old college student whom everyone agrees is doomed to die a virgin. Desperate to break what seems to be a cosmic curse, he tries ever more bizarre schemes to seduce one the sexy, scantily-clad women who seem to be everywhere, taunting him and enjoying his misery. Despite his best efforts, however, he is rejected everywhere, even at the local cathouse. When Pondo threatens to kill himself, Studley, his ladykilling best friend, tries to help him in his quest to "get him a little", as does Studley's mentor, a wise old janitor named Elbow.

A criminal gang commits a string of violent robberies and murders, culminating in the assassination of the police detective on the case, which may lead to their downfall.

Sam, a neurodivergent man, has a daughter with a homeless woman who abandons them when they leave the hospital, leaving Sam to raise Lucy on his own. But as Lucy grows up, Sam's limitations as a parent start to become a problem and the authorities take her away. Sam convinces high-priced lawyer Rita to take his case pro bono and in turn teaches her the value of love and family.

In 1970, Tony and Lawson started a cool club with the kids in the neighborhood, were boys could be boys. Now late into their 50's, the club is still going strong - too bad the same can't be said about their relationships.