Suffering from acute kidney failure, Boonmee has chosen to spend his final days surrounded by his loved ones in the countryside. Surprisingly, the ghost of his deceased wife appears to care for him, and his long lost son returns home in a non-human form. Contemplating the reasons for his illness, Boonmee treks through the jungle with his family to a mysterious hilltop cave—the birthplace of his first life.

In Thailand, an illegal immigrant from Myanmar with a mysterious skin rash, his girlfriend, and her friend visit the doctor's before spending the afternoon on individual and collective adventures.