Two lifelong friends have their lives shaken up when one of them discovers that he has cancer. Quick to lose hope in the face of his deteriorating health, it's left to his best friend to help him get through these troubled times.

Sikil tells the story of two men and a woman who are involved in a bizarre love triangle. These three friends grew up in a small town south of Manila. Enzo is a young closet gay prostitute who's obsessed with his childhood friend who happens to be a call-boy and has a girlfriend. Other interesting characters are the bi-sexual pimp, a regular bathhouse customer, and a sampaguita vendor-pickpocket-shoplifter and caretaker of Adong's daughter.