In 1968, in the Ravenside Military Hospital in a military facility in Pennsylvania, the army loses control of an experiment of a lethal bacteriologic weapon that changes the DNA and transforms human beings into zombies. A group of soldiers is sent to the hospital to eliminate the infected staff and interns but private DeLuca steals a test tube with the virus and hides it inside a vacuum flask. He is transformed into a zombie and killed but the vacuum flask falls in the grass. In the present days, a group of patients in the mental institution Ravenside Memorial Hospital finds the vacuum flask and later when one of them opens the vessel, the culture tube drops on the floor of a bathroom contaminating the group and their Dr. Donwynn.

In 1958 Nebraska, 19 year old garbageman Charles Starkweather goes on a murder spree with his 14 year old girlfriend Caril Ann Fugate. They kill 11 people in three months, introducing America to spree killing.

Upon arriving in Cartagena, Colombia, American pilot Benjamin Grey's passport and money are stolen leaving him stranded. Shortly after he receives a call from his son's doctor, who informs him that he is his Leukemia-stricken son's only chance for survival, and the clock is ticking

After a series of bad relationships, a man orders a mail order bride and receives more than he bargained for.