Gangstresses, a documentary by Harry Davis, tells the story of violence, poverty, and survival in the streets from a female perspective. Over a two-year period, Davis interviews female hustlers, drug dealers, rappers, porn stars, prostitutes, mothers, and daughters. Among them are Champagne, a well-known African American porn star who has a small child; Mama Mayhem, a street hustler; Uneek, a rapper from the Bronx; and Vanessa Del Rio, a famous porn actress. Musicians Lil' Kim, Mary J. Blige, Ice T, and Tupac Shakur also share personal stories of survival. The documentary conducts follow-up research on the women's complicated lives, offering glimpses of both tragic reality and hopeful recovery.

An unfulfilled engineer wakes up next to a ticking thermonuclear bomb in an underground chamber with only a phone and one instruction to save millions of people: she must convince the US President to kill himself.