The PFL 6 mixed martial arts event for the 2021 season of the Professional Fighters League was held on June 25, 2021. This was the third regular season event of the tournament and included fights in the Heavyweight and women's Lightweight divisions. This event will aire on ESPN2, with the prelims on ESPN+. The event was headlined by Two-time Olympic gold medalist Kayla Harrison and Cindy Dandois.

The event was headlined by a heavyweight bout, contested by the former UFC Heavyweight champion Fabrício Werdum and Renan Ferreira. In the co-main event, the 2019 PFL Lightweight champion Kayla Harrison fought Mariana Morais.