After crashing the family car, Juan encounters a cast of eccentric and fantastic characters who each try to help. But what begins as a mundane adventure quickly becomes a transformative journey exploring issues of death, family, love and sex.

Jamie is a boorish, insensitive American twentysomething traveling in Chile, who somehow manages to create chaos at every turn. He and his friends are planning on taking a road trip north to experience a legendary shamanistic hallucinogen called the San Pedro cactus. In a fit of drunkenness at a wild party, Jamie invites an eccentric woman—a radical spirit named Crystal Fairy—to come along.

Two high school students in Toluca glimpse the challenges and hard road of awakening to adulthood. Matilde wants to be a dentist and Yolanda longs to be a singer. Both face parental authority, experience the transition from adolescence to womanhood, and share the awakening of sexuality, the challenge to authority, the discovery of drugs, and political awareness.