A filmmaker facing an existential crisis goes on a vacation to a Mexican gay nudist beach, where he meets a social media celebrity who convinces him to collaborate with him on his new TV show. But one disappears and another embarks on a wild journey through Mexico City to find him.

Jamie is a boorish, insensitive American twentysomething traveling in Chile, who somehow manages to create chaos at every turn. He and his friends are planning on taking a road trip north to experience a legendary shamanistic hallucinogen called the San Pedro cactus. In a fit of drunkenness at a wild party, Jamie invites an eccentric woman—a radical spirit named Crystal Fairy—to come along.