Big Bertha is the popular, full-figured owner of the community's most successful whorehouse and moonshine racketeering enterprise. Some guys decide to rob Big Bertha’s stash of money, but the local cops just happen to coincidentally be "visiting" the joint. With her money missing, Big Bertha announces the closure of her whorehouse, but nobody in town will let that happen!

A black doctor ex-convict returns to the all-white town he knows as home and discovers a deadly disease threatening the citizens. He must fight prejudice and time if he is to save the town.