Relationship problems plague a family of siblings in director Catherine O. Camarillo's multilayered indie drama. Businessman Jimmy is reeling from the shock of being dumped by his fiancee, while his sisters cope with their own romantic woes. Leslie can't decide between two eligible bachelors, Annette nurtures a long-distance love, and housewife Claire can't get pregnant.

Hesus Resurreccion, a total scaredy cat who lives with his social-climbing aunt and two rowdy cousins, inherits an abandoned mansion. Coincidentally, the said location serves as a portal to the afterlife for the stranded ghosts, and they know that Hesus is "The One" who would open it. If he didn't, the ghosts would turn into cockroaches.

Rome and Juliet follows the romantic journey and soul mating of two straight women caught in a web of forbidden love. Juliet (a conservative pre-school teacher) is a bride to be who befriends and hires Rome (a liberated businesswoman) as her wedding planner. As they go through the preparations, Rome and Juliet develop a deep friendship, a soulful connection and a love that is physically consummated. But conflicts arise when Marc, the groom, who is a young politician, shockingly discovers the ongoing relationship between the two women. Angered and humiliated, Marc calls off the wedding and a huge scandal explodes, leaving Rome and Juliet in a state of emotional turmoil.

Angelo (Eigenmann) is an orphan who turns into a serial killer. Despite the efforts of rehabilitation, psychological turmoil still haunts and prevents him from living a peaceful and ordinary life. Faced with this reality, Angelo searches for a way to exorcise his personal demons. In the end, he gets his just reward when he crosses paths with a demon that he himself created.