Frank Drebin is persuaded out of retirement to go undercover in a state prison. There he has to find out what top terrorist, Rocco, has planned for when he escapes. Adding to his problems, Frank's wife, Jane, is desperate for a baby.

Under the watchful eye of his mentor, Captain Mike Kennedy, probationary firefighter Jack Morrison matures into a seasoned veteran at a Baltimore fire station. However, Jack has reached a crossroads as the sacrifices he's made have put him in harm's way innumerable times and significantly impacted his relationship with his wife and kids.