A down-and-out writer, Nick Sennet, runs into Harry, a man that, legend has it, died long ago. Together they attempt to revitalize a defunct factory as well as their lives.

In the fall of 1963, Eddie Birdlace is an 18-year-old Marine Corps volunteer who is about to ship out with three of his buddies for a tour of duty in Vietnam. Planning a massive blowout for their last night in San Francisco, Eddie, his buddies, and a number of other Marines set up a contest they call a "dogfight”.

Four actors compete for the role of Jesus - a black revolutionary, a bisexual hippie, a Jew, and a feminist. When all four are rejected, they hit the road on bad-ass motorcycles, bound for glory in New York City. But when a run-in with a gang of Elvises ends in murder, they find themselves taken prisoner in a little town called Jackville - where folk don't take kindly to blasphemers. The Jesuses fall prey to an evil conspiracy that can only lead to the Apocalypse.