After his first date at age 15 ended with the girl making out with another man at a party, aspiring writer Lester Grimm has treated all his girlfriends with jealousy and suspicion. While dating Ramona Ray, paranoia gets the best of him when he discovers that her most recent ex is successful novelist Dashiell Frank. Lester begins attending the same group therapy sessions as Dashiell to learn about Ramona's past with him.

After her husband is arrested for looting, Lisette struggles for independence while dealing with her transgender sibling, her critical mother-in-law and assorted neighborhood eccentrics.

Bertram Pincus, a cranky, people-hating Manhattan dentist, develops the unwelcome ability to see dead people. Really annoying dead people. Even worse, they all want something from him, particularly Frank Herlihy, a smooth-talking ghost, who pesters him into a romantic scheme involving his widow Gwen. They are soon entangled in a hilarious predicament between the now and the hereafter!

Xavier is a 40-year-old father of two who still finds life very complicated. When the mother of his children moves to New York, he can't bear them growing up far away from him and so he decides to move there as well.

An aging publisher becomes a demon wolf and, with this newfound youthful vigor, fights to keep his job.

In the rail yards of Queens, contractors repair and rebuild the city's subway cars. These contracts are lucrative, so graft and corruption are rife. When Leo Handler gets out of prison, he finds his aunt married to Frank Olchin, one of the big contractors; he's battling with a minority-owned firm for contracts.

An ex-con's future is threatened by his brother's involvement with drugs.

A mediocre musician goes on the road in search of the world's greatest guitar maker.

When a vengeful New York transit cop decides to steal a trainload of subway fares, his foster brother—a fellow cop—tries to protect him.

Two aging comedians, who acrimoniously dissolved their act eight years earlier, must overcome their differences when they have the chance for a lucrative movie comeback.