A wrestling hero helps the police in their battle against a mad doctor and his army of female zombies.

In the Age of the Inquisitions, 1603, Santo, El Enmascarado de Plata, is being laid to rest by a group of monks. The Black Hood, an axe-wielder and a tormented soul who sold his soul to the devil after losing his love to El Santo, appears at the foot of his tomb and swears to seek his revenge no matter how many centuries it takes. El Santo is the chosen one and is sworn to fight for good and justice at any cost. After he finds his love, Alicia, dead at the hands of the Black Hood, El Santo must trust his faith and use his strength in this battle of good vs. evil.

Landru, a French businessman, arrives Mexico with the idea of ​​promoting their fighters, what nobody knows is that besides Landru promoter and fighter is a mad scientist who seeks to alter human genetics mixing it with the animal to make stronger and fiercer to their gladiators.