An eclectic group of strangers seek shelter on a dark and stormy night, soon finding an isolated guest house owned by a mysterious proprietor.

Dr. George Medeiros, a brilliant scientist, is badly disfigured when his wife takes a lover and plans to murder him. After months in the hospital, he returns with nothing in mind but revenge.

A psychiatric doctor driven to insanity by nightmare visions of Zé do Caixão trying to steal his wife is helped by colleagues who enlist creator José Mojica Marins to convince the patient that he does not exist.