Just as her life is coming together, Allison experiences a terrible tragedy when her boyfriend is murdered by an intruder from whom the woman herself barely escapes. The police capture a man they believe to be the killer, but Allison, still unsettled, has her doubts. Things take a frightening turn when she meets her friend's new boyfriend and suspects him to be the killer.

Three stories about the world of opioids collide: a drug trafficker arranges a multi-cartel Fentanyl smuggling operation between Canada and the U.S., an architect recovering from an OxyContin addiction tracks down the truth behind her son's involvement with narcotics, and a university professor battles unexpected revelations about his research employer, a drug company with deep government influence bringing a new "non-addictive" painkiller to market.

Philly is deeply troubled by the fact that his mother recently sent his older brother Morris to live at a mental health facility. While wandering about on a day that he decides to skip school, Philly learns of one particular historical incident that sheds new light on his brother's and mother's predicament. The Horse Latitudes is a psychological drama that probes popular perceptions of "conformity" and "freedom", and asks what it takes to be functional.