Hoppy goes undercover as an outlaw (which permits him, for once, to drink and be mean to children) to track down a bunch of outlaws operating along the border. Loco, the head bad guy, deflects suspicion from himself by pretending to be a moron.

The Cattlemen's Association has called in the Mesquiteers to find cattle rustlers. They get Tex Riley to pose as Stony so Stony can arrive posing as a wanted outlaw. This gets Stony into the gang of rustlers and he alerts Tucson and Lullaby as to the next raid. But Hartley is on hand and unknown to anyone is the rustler's boss and he joins the posse with a plan that will do away with the Mesquiteers.

An orphan whose father has been killed by bandits inherits a mine. Cisco saves the mine and the child and also finds the child's real mother.

Lorna Drake has inherited a ranch. Hoppy teaches her a bit about ranching and handles Scar Lewis, the bad guy, in the process.

Homesteaders are moving into the valley settled many years ago by rancher Craig Dolan. He wants to keep them out by legal means but his nephew Bart brings in outlaws to drive them out. The Lone Ranger is on hand to help the homesteaders battle Bart's men as he overcomes traps, ambushes, burning buildings and other obstacles in his attempt to bring peace to the valley.

On a cattle drive Hoppy, camp cook Windy, companion Lucky, and young Artie Peters encounter an eccentric professor. The professor professes to be searching for the evolutionary missing link, but in reality he is a cattle rustler who uses his dynamite to scatter the cattle in order capture some of them. Hoppy and Bar 20 guys ultimately capture the professor.

Hopalong Cassidy, boss of the Bar 20 ranch in Texas, rides down the Camino Real in the New Mexico cattle country near Alamogordo, in response to an urgent message from his lifelong sweetheart, Nora Blake, who is in serious trouble. Before he and his saddlemates, "Lucky" Jenkins and "Pappy", can reach her ranch, they are stopped by Clay Allison, a cattle-rustler who is in almost complete control of the district, and wants to extend his holdings by seizing Nora's cattle and driving her out. Seeing Cassidy as a menace to his plans, he has him arrested on a trumped-up charge. Cassidy and his pals shoot their way out of the trouble and reach Nora;s ranch where they learn that Allison's henchmen have murdered her foreman, Tom Dillon, and Allison has sent for a crew of outlaws on the Texas border.

Hoppy, Johnny and Windy are fighting a malicious gang trying to stop a cattle drive from reaching a drought-stricken North.

Will Parker has been destroyed by a local politician and now must steal to feed his family. He steals a steer from the Three Mesquiteers.

An intellectually disabled giant and his level headed guardian find work at a sadistic cowboy's ranch in depression era America.