Best friends since they were kids, Rabbi Jacob Schram and Father Brian Finn are dynamic and popular young men living and working on New York's Upper West Side. When Anna Reilly, once their childhood friend and now grown into a beautiful corporate executive, suddenly returns to the city, she reenters Jake and Brian's lives and hearts with a vengeance. Sparks fly and an unusual and complicated love triangle ensues.

After the lord of darkness decides he will not cede his throne to any of his three sons, the two most powerful of them escape to Earth to create a kingdom for themselves. This action closes the portal filtering sinful souls to Hell and causes Satan to wither away. He must send his most weak but beloved son, Little Nicky, to Earth to return his brothers to Hell.

An ultraconservative police officer suffers a debilitating stroke and is assigned to a rehabilitative program that includes singing lessons - with the drag queen next door.