Two college drop outs, Lee and Moe spend their time days getting high and doing Laundry on the weekends but after smoking a laced joint. Moe cant figure out what's real or fantasy as he contemplating his life choices.

In San Francisco, Jill Valentine is dealing with a zombie outbreak and a new T-Virus, Leon Kennedy is on the trail of a kidnapped DARPA scientist, and Claire Redfield is investigating a monstrous fish that is killing whales in the bay. Joined by Chris Redfield and Rebecca Chambers, they discover the trail of clues from their separate cases all converge on the same location, Alcatraz Island, where a new evil has taken residence and awaits their arrival.

In 2100, when humanity has abandoned the earth, a colony of extravagant creatures still thrives in the deepest abyss of the ocean.