A New York City-set drama of interlocking stories which occur over a 36-hour period.

Leo and Angela Russo live a simple life in Queens, surrounded by their overbearing Italian-American family. When their son finds success on his high school basketball team, Leo tears the family apart trying to make it happen.

Paul Aufiero, a 35-year-old parking-garage attendant from Staten Island, is the self-described "world's biggest New York Giants fan". One night, Paul and his best friend Sal spot Giants star linebacker Quantrell Bishop at a gas station and decide to follow him. At a strip club Paul cautiously decides to approach him but the chance encounter brings Paul's world crashing down around him.

Pennsylvania, 1956. Frank Sheeran, a war veteran of Irish origin who works as a truck driver, accidentally meets mobster Russell Bufalino. Once Frank becomes his trusted man, Bufalino sends him to Chicago with the task of helping Jimmy Hoffa, a powerful union leader related to organized crime, with whom Frank will maintain a close friendship for nearly twenty years.