In 1927 Hollywood, a silent film star falls for a chorus girl just as he and his paranoid screen partner struggle to make the difficult transition to talking pictures.

An angry Seminole chief wages war after his tribe is relocated from Florida to the American West.

Jobless sportswriter Eddie Willis is hired by corrupt fight promoter Nick Benko to promote his current protégé, an unknown Argentinian boxer named Toro Moreno. Although Moreno is a hulking giant, his chances for success are hampered by a powder-puff punch and a glass jaw. Exploiting Willis' reputation for integrity and standing in the boxing community, Benko arranges a series of fixed fights that propel the unsophisticated Moreno to #1 contender for the championship. The reigning champ, the sadistic Buddy Brannen, harbors resentment at the publicity Toro has been receiving and vows to viciously punish him in the ring. Eddie must now decide whether or not to tell the naive Toro the truth.

Columbia Pictures elevated a run-of-the-mill B-western supporting player, Marshall Reed, to the title role in this equally run-of-the-mill western serial released in 15 chapters. Like most serials in the '50s, Riding with Buffalo Bill consisted of quite a bit of budget-stretching stock footage telling a highly fictionalized account of Buffalo Bill Cody aiding a group of ranchers in their defeat of a local crime lord. The serial's assistant director, Leonard Katzman, later produced the long-running television series Gunsmoke and Dallas.