In London, barrister Anthony Keane takes the case of Maddalena Paradine, a beautiful woman accused of poisoning her blind husband. Though happily married, Keane becomes infatuated with his enigmatic client and convinced of her innocence. His obsession clouds his judgment as he builds a defense implicating her servant, André Latour—an act that leads to devastating consequences both in court and at home.

Beautiful half-breed Pearl Chavez becomes the ward of her dead father's first love and finds herself torn between her sons, one good and the other bad.

Cleve Marshall, an assistant district attorney, falls for Thelma Jordon, a mysterious woman with a troubled past. When Thelma becomes a suspect in her aunt's murder, Cleve tries to clear her name.

Duncan Craig signs on a whaling ship, partly because his own business deal has fallen through, partly to help Judie Nordhall find her father. Rumor has it that her father may have been murdered by Erik Bland, son of her father's partner and her one-time lover. Duncan and Erik find themselves on rival whaleboats and, ultimately, on an ice floe.

Carl Brown and Annie McGairy are in love. Their Irish immigrant parents knew each other in the old country - and Carl's parents want better for their son than Annie, who was raised in the slums. When Annie runs away to marry Carl while he's at college, they have many difficulties, including a college Dean that frowns upon married couples, Carl's angry parents, Carl's jealousy, and Annie's own problems with her sexuality.