Clips from assorted television programs, B-movies, commercials, music performances, newsreels, bloopers, satirical short films and promotional and government films of the 1950s and 1960s are intercut together to tell a single story of various creatures and societal ills attacking American cities.

When the first manned flight to Venus returns to Earth, the rocket crash-lands in the Mediterranean near a small Italian fishing village. The locals manage to save one of the astronauts Colonel Calder, the mission commander. A young boy also recovers what turns out to be a specimen of an alien creature. Growing at a fantastic rate, it manages to escape and eventually threatens the city of Rome.

Test space rockets exploding at liftoff and increased reporting of UFO sightings culminate in a direct attempt by alien survivors of a dead, extra-galactic civilization to invade Earth from impervious flying saucers, using ray-weapons of mass destruction.

Jeanne, a high school girl, dumps her dull boyfriend Larry for Nick, a local thug and hot-rodder she finds exciting. Nick terrifies everyone with his dangerous and reckless driving, but that only turns Jeanne on even more. Until one night, zooming around the countryside terrorizing motorists, Nick and Jeanne smash into another car...

An inmate is persuaded to take part in a breakout by cellmates anxious to cash in on loot they believe she has hidden.

Wally Hogan has things going his way. He is the manager-trainer of Bullet Bradley, a fighter who has just won the lightweight championship. However, life suddenly takes a not-so-happy turn when Bullet gets drafted.

An Indian and his beautiful sister attempt to destroy a cavalry patrol trying to deliver a peace treaty to their chief.

The only white survivor of a Crow Indian raid on a wagon train is a young boy. He is rescued by the Sioux, and the Sioux chief raises him as an Indian in very way. Years later, the white men and the Sioux threaten to go to war and the Indian-raised white man is torn between his racial loyalties and his adopted tribe.

The friendship between a white man & an Apache chief is tested when they fall in love with the same woman

A government agent ventures west to look into reports that Apaches are behind a recent wave of frontier attacks. Begins to suspect a set-up.