An insurance agent's greedy girlfriend with a taste for mink leads him to a life of crime.

A doctor testing drugs on convicts gets mixed up in a murder investigation.

Police sergeants Johnson and McManus take on Los Angeles confidence tricksters. Con man Tony Wells, lining up rich widow Jessica Royce as his latest mark, sets up a false paranormal society with other charlatans to convince the credulous Jessica that her late son is speaking to her through their sham seances. When the plan leads to murder, Johnson and McManus must bring the group down before they kill again.

Parolee John Carver seeks the stolen money he has hidden, but so does his girlfriend, lawyer and cellmate. Tom and Chito are hired to get him across the border into Mexico and find themselves caught in the middle.

The Texas Rangers send Dave and Chito into the badlands to see if they can locate a counterfeiting operation. They arrive posing as wanted outlaws and this gets them into the gang. But as soon as they uncover the operation and locate the printing press, one of Chito's girl friends arrives to expose their identity and they find themselves trapped by the entire gang.

Landry has Sam Martin killed. When Tim and Chito find Martin and his son, Chip says Matt Potter was responsible. But when Tim and Chito start their search, no ones knows a Matt Potter.

Two men are accused of killing their boss. They are saved from the hangman's noose when two other guys are arrested, but Holt feels as though justice is still not being served. On their own, they set about to track down the genuine killer.

Recently released from prison, nice guy Dave Collins finds himself unwillingly mixed up with his old outlaw acquaintances Turk Thorne and his gang as they try to use his telegraphy talents to zero in on the arrival of a gold shipment on the local train. Taking a liking to Collins, cowboys Tim Holt and Chito Rafferty get him to agree to help set a trap for the train robbers

With the help of Pocahontas, Captain John Smith overcomes the treachery of some of his men and resentment of the local Native Americans to establish the colony of Jamestown.