Martin Cooper’s documentary feature explores the lives and work of six internationally renowned, independent animators and animation directors. These multi-award-winning artists are Jim Blashfield, Rose Bond, Joan C. Gratz, Zak Margolis, Joanna Priestley and Chel White. Their animated films span a period of over 40 years and reflect a wide range of techniques, from direct animation and classic stop-motion, through 3D models, clay painting, computer-generated imagery up to AI. History, Mystery & Odyssey is entirely filmed in Portland Oregon, where all these animators live and work.

Walt Disney said “We have created characters and animated them in the dimension of depth, revealing through them to our perturbed world that the things we have in common far outnumber and outweigh those that divide us.” Outside of Walt himself there are few people who have brought together and united more animators in the history of the genre than Craig "Spike" Decker and Mike Gribble, known to all as Spike & Mike. They created an animation festival that helped launch the careers of John Lasseter, Peter Lord, Will Vinton, Bill Plympton and Mike Judge to name just a few. Their Spike & Mike festival had an enormous impact on animation that was felt the world over. The festival was known as much for the breakthrough animation it presented as the outrageous antics of the founders.