The demon lives and its power grows into the immeasurable! Ed Hauser's assistant freed himself the spell of the demon and flees Mr. Goldmann to tell the horrible truth. The final annihilation of humanity has started...

A condensed version of Mutation 2: Generation Dead and Mutation 3: Century of the Dead, Mutation Annihilation follows the remaining survivors of a plague-infested Germany as they fight for survival against the mutated humans they once called their kin. As the plague spreads, turning more and more into monsters, a band of warriors emerge to stop the madness once and for all.