In the 1970s on the Binlusai islands, a young mother is killed when she was running with her son run from an evil presence in an abandoned Roman Catholic leper colony. In the present day, a group of four young men and women are travelling to the island to take part in a survival game run by TV channel Search Planet headed by Chen Jiadong (Philip Keung). Also on the boat is the television presenter Stanley (Jessica Xu) and cameraman Ken (Shaun Tam). The eight people have been split into four pairs where they are given a map which leads to a flag; their aim is to survive without any supplies, and the winning duo gets a grand prize of one-million dollars. As they approach the island, their ship is attacked by something unknown under the water and most of their luggage is lost. Shen Yilin (Mini Yang) has preserved her map which she gives to her partner Peng Fei (Jordan Chan).

Five graduates from different years come together to celebrate their secondary school teacher Master Jude's 80 year-old birthday. Master Jude is a happy-go-lucky bachelor who enlightened them on the matter of sex during their school days. Since all of the five men have marital problems, this is a good time for them to meet and share their grievances. However, during the celebration party held in a hotel, they encounter 5 pretty, sexy young models. They fall for each other and have a love-fest in the hotel.

Eric (Alex Fong Lik-Sun) and Cheun (Sammy) are two medical students who opt to rent a flat in a secluded housing estate, the reason being to concentrate on their upcoming exams. Their best intentions go south damn quick; first of all, Cheun wastes time and acts extremely annoying, thereby ruining any chance at serious study time. Second, there may be vampires in the building. Eric becomes slightly enamored of Jade (Miki Lee), a pretty young thing who lives in the building with her older sisters (Zuki Lee and Cynthia Ho). But after a series of weird noises and the appearance of a man bleeding from the neck, Eric thinks something may be up. He enlists the help of TV occult expert Mister M (Yuen Wah), who all but confirms Eric's suspicions: the sisters are vampires. Worse, they must suck the life out of one good man to cure their aversion to daylight, and have ear-marked Eric as the designated \"good man\".