THE BEST OF IT takes an unflinching look at the life of a professional gambler. The character driven documentary focuses on the lives of Boston, The Shrink, Dink, and Banker who all chose to make a living betting sports. A gambler selects this profession despite knowing the life they fancied tends to chew up and spit out even the most seasoned gambler—an all too common tale in Las Vegas. A feud between Boston and The Shrink develops after accusations are made about gambling debts, but a gambler’s actual bank account balance is often based on rumors and half-truths. The outcome of a gambler is as unpredictable as the the games they bet.

John Walsh presents various theories regarding the mystery of "Who Shot Mr. Burns?"