Robert Guerrero takes on Yoshihiro Kamegai in his first fight in over a year, Gary Russell takes on Vasyl Lomachenko in a match pitting two potential superstars against one another, and Devon Alexander looks to bounce back from defeat against the always rugged Jesus Soto-Karass.

Manny Pacquiao vs. Antonio Margarito, billed as World Super Welterweight Championship, was a Super Welterweight fight for the WBC Super Welterweight championship. The bout was held on November 13, 2010, at Cowboys Stadium, in Arlington, Texas, United States. The match was put together after the second negotiation for the long awaited "superfight" between Manny Pacquiao and Floyd Mayweather, Jr. had failed. Pacquiao defeated Margarito by unanimous decision.