When Harvard PhD student Jennifer Brea is struck down at 28 by a fever that leaves her bedridden, doctors tell her it’s "all in her head." Determined to live, she sets out on a virtual journey to document her story—and four other families' stories—fighting a disease medicine forgot.

Scott Gamble waits anxiously in the Emergency Room to hear the status of his little sister. After overhearing the nursing staff whispering about the superstitions surrounding Room 566, where his sister is to be placed overnight, he must get her out of the room before it's too late.