Cannibal Taboo tells the story of Janet, a young woman raised in the wilds of Africa who is rescued by explorer Cliff Hendricks. When Cliff contracts a rare blood disease, Janet must leave her jungle ways to care for her husband and their four children. The bulk of the plot occurs when the youngest son, Paul, is about to have his twenty-first birthday. His brother Luke, a successful professor, returns for the celebration. However, things are not so simple in the Hendricks household, since fourth sibling Matthew disappeared on his twenty-first. Moreover, Paul and his sister have an incestuous relationship, and Janet is harboring a terrible secret.

Fay is a small town girl on a cross country road trip, trying to escape her own reality after the death of her father. When her muscle car breaks down during a drag race she finds herself stranded along route 66 in an isolated desert town. Short on cash, she makes a series of choices to make enough money to repair her car. After encountering a neurotic, drug abusing clown she finds herself sliding down a dark spiral. Soon thereafter, her road trip starts to devolve into a living nightmare. Trapped and desperate, she fights to regain her identity while navigating through a host of locals; a creepy motel clerk, an overzealous preacher, and a sexy temptress with horns and a tail.